This brief introduces collaborative learning as an effective approach to support sustainable health system strengthening. Collaborative learning brings together local leaders and experts to learn from one another, problem-solve, co-create new knowledge, and adapt and apply their learning. Collaborative learning can be incorporated within HSS programs as an alternative or complementary model of technical assistance. With strong participant engagement and effective facilitation, it has the potential to strengthen health systems and accelerate progress towards improved health outcomes in low and middle-income countries